Article
Identification of a gene involved in plasmid structural instability in Corynebacterium glutamicum.
Applied microbiology and biotechnology - 1 Sept 2013
Kitade Yukihiro, Okino Shohei, Gunji Wataru, Hiraga Kazumi, Suda Masako, Suzuki Nobuaki, Inui Masayuki, Yukawa Hideaki
Abstract excerpt
Expression plasmids that facilitate production of bio-based products are susceptible to toxic effects that frequently affect plasmid structural stability in recombinant microbial cells. In order to enhance plasmid stability in recombinant Corynebacterium glutamicum, an expression plasmid containing genes of the Clostridium acetobutylicum butyryl-CoA synthesis operon with high structural instability within...
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