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Multisample aCGH Data Analysis via Total Variation and Spectral Regularization

1 Jan 2013

Abstract excerpt

DNA copy number variation (CNV) accounts for a large proportion of genetic variation. One commonly used approach to detecting CNVs is array-based comparative genomic hybridization (aCGH). Although many methods have been proposed to analyze aCGH data, it is not clear how to combine information from multiple samples to improve CNV detection. In this paper, we propose to use a matrix to approximate the multisample...

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PMID: 23702561
DOI: 10.1109/tcbb.2012.166

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