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Article

An optimization framework for unsupervised identification of rare copy number variation from SNP array data.

Genome biology - 1 Jan 2009

Yavas Gökhan, Koyutürk Mehmet, Ozsoyoğlu Meral, Gould Meetha P, LaFramboise Thomas

Abstract excerpt

Copy number variants (CNVs) have roles in human disease, and DNA microarrays are important tools for identifying them. In this paper, we frame CNV identification as an objective function optimization problem. We apply our method to data from hundreds of samples, and demonstrate its ability to detect CNVs at a high level of sensitivity without sacrificing specificity. Its performance compares favorably with...

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Identifiers

PMID: 19849861
DOI: 10.1186/gb-2009-10-10-r119
PMCID: PMC2784334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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