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Article

A pipeline for copy number variation detection based on principal component analysis.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference - 1 Jan 2011

Chen Jiayu, Liu Jingyu, Boutte David, Calhoun Vince D

Abstract excerpt

DNA copy number variation (CNV), an important structural variation, is known to be pervasive in the human genome and the determination of CNVs is essential to understanding their potential effects on the susceptibility to diseases. However, CNV detection using SNP array data is challenging due to the low signal-to-noise ratio. In this study, we propose a principal component analysis (PCA) based approach for data...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22255943
DOI: 10.1109/IEMBS.2011.6091763
PMCID: PMC4197848

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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