Article
Monoallelic chromatin conformation flanking long-range silenced domains in cancer-derived and normal cells.
PloS one - 1 Jan 2013
Di Paola Domenic, Raelson John, Rampakakis Emmanouil, Basik Mark, Zannis-Hadjopoulos Maria, Bradley W Edward C
Abstract excerpt
Epigenetic inactivation of chromatin plays an important role in determining cell phenotype in both normal and cancer cells, but our knowledge is still incomplete with respect to any potential monoallelic nature of the phenomenon. We have genotyped DNA isolated from chromatin of two colorectal cancer-derived lines and a culture of normal human intestinal epithelial cells (HIEC), which was immunoprecipitated with...
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