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Article

3'-Azido-3'-deoxythymidine inhibition of human lymphocyte cytolytic function in vitro.

Biochemical pharmacology - 15 Jan 1991

Shaw D R, Knight D R, Waterman A L, Sommadossi J P

Abstract excerpt

Despite administration of 3'-azido-3'-deoxythymidine (AZT, Zidovudine) to seriously immunocompromised patients, little has been reported regarding effects of AZT on specific immune functions. This study analyzed the in vitro effect of AZT on normal human lymphocyte cytolytic activity. AZT at concentrations up to 100 microM had no effect when added directly to cytotoxicity assays with lymphocyte effector cells and...

Topics

Acyclovir
Cell Survival
Cells, Cultured
Cytotoxicity Tests, Immunologic
Ganciclovir
Humans
Interleukin-2
Phenotype
Recombinant Proteins
T-Lymphocytes, Cytotoxic
Zidovudine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1989638
DOI: 10.1016/0006-2952(91)90488-q

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1989638-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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