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Differential Incorporation and Removal of Antiviral Deoxynucleotides by Human DNA Polymerase γ

1 Jun 2001

Abstract excerpt

Mitochondrial toxicity can result from antiviral nucleotide analog therapy used to control human immunodeficiency virus type 1 infection. We evaluated the ability of such analogs to inhibit DNA synthesis by the human mitochondrial DNA polymerase (pol gamma) by comparing the insertion and exonucleolytic removal of six antiviral nucleotide analogs. Apparent steady-state K(m) and k(cat) values for insertion of...

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PMID: 11319228
DOI: 10.1074/jbc.m101114200

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