Article
Efffect of the ABCC3 -211C/T polymorphism on clopidogrel responsiveness in patients with percutaneous coronary intervention.
Clinical and experimental pharmacology & physiology - 1 Aug 2013
Zou Jian-Jun, Fan Hong-Wei, Chen Shao-Liang, Tan Jie, He Bang-Shun, Xie Hong-Guang
Abstract excerpt
Multidrug resistance protein 3 (MPR3), encoded by the ATP-binding cassette, subfamily C (CFTR/MRP), member 3 (ABCC3) gene, functions as an important drug efflux transporter. The ABCC3 -211C/T polymorphism is associated with decreased MRP3 mRNA expression, and low MRP3 mRNA expression is associated with increased clopidogrel response in patients. The aim of the present study was to determine whether the -211C/T...
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