Article
No association of ABCB1 C3435T genotype with clopidogrel response or risk of stent thrombosis in patients undergoing coronary stenting.
Circulation. Cardiovascular interventions - 1 Feb 2012
Jaitner Juliane, Morath Tanja, Byrne Robert A, Braun Siegmund, Gebhard Daniela, Bernlochner Isabell, Schulz Stefanie, Mehilli Julinda, Schömig Albert, Koch Werner, Kastrati Adnan, Sibbing Dirk
Abstract excerpt
BACKGROUND: The prodrug clopidogrel requires intestinal absorption by the efflux pump P-glycoprotein MDR1 (multidrug resistant-1), encoded by the ABCB1 gene. Prior studies suggested that a common and functional genetic variant (C3435T, rs1045642) within ABCB1 influences clopidogrel treatment efficacy; however, existing data are highly inconsistent, because other studies failed to replicate this postulated...
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