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Article

Impact of P-glycoprotein on clopidogrel absorption.

Clinical pharmacology and therapeutics - 1 Nov 2006

Taubert Dirk, von Beckerath Nicolas, Grimberg Gundula, Lazar Andreas, Jung Norma, Goeser Tobias, Kastrati Adnan, Schömig Albert, Schömig Edgar

Abstract excerpt

OBJECTIVE: The antiplatelet activity of clopidogrel is characterized by considerable interindividual differences. Variable intestinal absorption is suggested to contribute to the inconsistencies in response. We tested the hypothesis that the intestinal efflux transporter P-glycoprotein (P-gp) limits the oral bioavailability of clopidogrel and that variance in the MDR1 gene encoding P-gp predicts absorption...

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Source

Identifiers

PMID: 17112805
DOI: 10.1016/j.clpt.2006.07.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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