Article
Epigenetic regulation in the pathophysiology of Alzheimer's disease.
Progress in neurobiology - 1 Apr 2010
Chouliaras Leonidas, Rutten Bart P F, Kenis Gunter, Peerbooms Odette, Visser Pieter Jelle, Verhey Frans, van Os Jim, Steinbusch Harry W M, van den Hove Daniel L A
Abstract excerpt
With the aging of the population, the growing incidence and prevalence of Alzheimer's disease (AD) increases the burden on individuals and society as a whole. To date, the pathophysiology of AD is not yet fully understood. Recent studies have suggested that epigenetic mechanisms may play a pivotal role in its course and development. The most frequently studied epigenetic mechanisms are DNA methylation and histone...
Topics
- Aging
- Alzheimer Disease
- Animals
- DNA Methylation
- Environment
- Epigenesis, Genetic
- Gene Expression Regulation
- Genetic Predisposition to Disease
- Histones
- Humans