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Article

MT1-MMP-dependent control of skeletal stem cell commitment via a β1-integrin/YAP/TAZ signaling axis.

Developmental cell - 28 May 2013

Tang Yi, Rowe R Grant, Botvinick Elliot L, Kurup Abhishek, Putnam Andrew J, Seiki Motoharu, Weaver Valerie M, Keller Evan T, Goldstein Steven, Dai Jinlu, Begun Dana, Saunders Thomas, Weiss Stephen J

Abstract excerpt

In vitro, topographical and biophysical cues arising from the extracellular matrix (ECM) direct skeletal stem cell (SSC) commitment and differentiation. However, the mechanisms by which the SSC-ECM interface is regulated and the outcome of such interactions on stem cell fate in vivo remain unknown. Here we demonstrate that conditional deletion of the membrane-anchored metalloproteinase MT1-MMP (Mmp14) in...

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Identifiers

PMID: 23685250
DOI: 10.1016/j.devcel.2013.04.011
PMCID: PMC3736823

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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