Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Linkage of bacterial colonization of skin and the urticaria-like rash of NLRP3-mediated autoinflammatory syndromes through mast cell-derived TNF-α.

Journal of dermatological science - 1 Aug 2013

Nakamura Yuumi, Kambe Naotomo

Abstract excerpt

As anti-cytokine therapies were developed for clinical use during the last decade, anti-IL-1 therapies have emerged as a highly effective treatment for cryopyrin-associated periodic syndromes (CAPSs), including the "urticaria-like rash." Based on clinical observations, we hypothesized that NLPR3 activation and IL-1β production, in particular in mast cells (MCs), are important for the development of this eruption,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cryopyrin-Associated Periodic Syndromes
Share to Exanthema

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interleukin-1beta

Share to Mast Cells

Share to NLR Family, Pyrin Domain-Containing 3 Protein

Share to Tumor Necrosis Factor-alpha

Share to Urticaria

Source

Identifiers

PMID: 23684246
DOI: 10.1016/j.jdermsci.2013.04.009

Genes

CAPS
TNF
NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Linkage of bacterial colonization of skin and the urticaria-like rash of NLRP3-mediated autoinflammatory syndromes through mast cell-derived TNF-α.PMID 23684246Read ↗

Critical role for mast cells in interleukin-1β-driven skin inflammation associated with an activating mutation in the nlrp3 protein.Semantic proximity Read ↗

Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndromeSemantic proximity Read ↗

New insights into the nature of autoinflammatory diseases from mice with Nlrp3 mutations.Semantic proximity Read ↗

A Knock-In Mouse Model of Cryopyrin-Associated Periodic Syndromes.Semantic proximity Read ↗

Interleukin-1, inflammasomes, autoinflammation and the skinSemantic proximity Read ↗

Immunology in clinic review series; focus on autoinflammatory diseases: role of inflammasomes in autoinflammatory syndromes.Semantic proximity Read ↗

[CAPS: cryopyrin-associated periodic syndrome].Semantic proximity Read ↗

Equally potent: Nlrp3 mutation in macrophages or neutrophils is sufficient to drive autoinflammation.Semantic proximity Read ↗

Pathogenic NLRP3 mutants forms constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β productionSemantic proximity Read ↗

Remodelling of the gut microbiota by hyperactive NLRP3 induces regulatory T cells to maintain homeostasis.Semantic proximity Read ↗

Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies.Semantic proximity Read ↗

Muckle-Wells Syndrome: A Case Report with an NLRP3 T348M Mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.