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Article

KIT-Targeting Drugs in the Management of Nonadvanced and Advanced Systemic Mastocytosis.

The journal of allergy and clinical immunology. In practice - 1 Jan 2026

Reiter Andreas, Rossignol Julien, Deininger Michael W, Luebke Johannes, Hermine Olivier, Akin Cem, Gotlib Jason, Radia Deepti H

Abstract excerpt

Systemic mastocytosis (SM) is a rare hematological neoplasm driven by the KIT D816V mutation in up to 95% of cases. SM is classified into nonadvanced SM-comprising indolent SM (ISM), bone marrow (BM) mastocytosis, and smoldering SM-and advanced SM (AdvSM), with the subtypes aggressive SM, SM with an associated hematological neoplasm (SM-AHN according to the World Health Organization), and mast cell (MC) leukemia....

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Share to KIT gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41187902
DOI: 10.1016/j.jaip.2025.10.034

Genes

KIT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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