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Article

Nanos3 gene targeting in medaka ES cells.

International journal of biological sciences - 1 Jan 2013

Guan Guijun, Yan Yan, Chen Tiansheng, Yi Meisheng, Ni Hong, Naruse Kiyoshi, Nagahama Yoshitaka, Hong Yunhan

Abstract excerpt

Gene targeting (GT) by homologous recombination offers the best precision for genome editing in mice. nanos3 is a highly conserved gene and encodes a zinc-finger RNA binding protein essential for germ stem cell maintenance in Drosophila, zebrafish and mouse. Here we report nanos3 GT in embryonic stem (ES) cells of the fish medaka as a lower vertebrate model organism. A vector was designed for GT via homologous...

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Identifiers

PMID: 23678294
DOI: 10.7150/ijbs.6507
PMCID: PMC3654493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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