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Article

RAGE-mediated interstitial fibrosis in neonatal obstructive nephropathy is independent of NF-κB activation.

Kidney international - 1 Nov 2013

Gasparitsch Mojca, Arndt Anne-Karin, Pawlitschek Felix, Oberle Stephan, Keller Ursula, Kasper Michael, Bierhaus Angelika, Schaefer Franz, Weber Lutz T, Lange-Sperandio Bärbel

Abstract excerpt

Urinary tract obstruction during nephron development causes tubular apoptosis, tubular atrophy, and interstitial fibrosis. Leukocyte recruitment is critical in the development of obstructive nephropathy leading to interstitial inflammation and renal fibrosis. RAGE, the receptor of advanced glycation end products, is implicated in chronic inflammation and has been recently identified as a novel receptor for the...

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Identifiers

PMID: 23677242
DOI: 10.1038/ki.2013.171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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