Article
A structural role for the PHP domain in E. coli DNA polymerase III.
BMC structural biology - 14 May 2013
Barros Tiago, Guenther Joel, Kelch Brian, Anaya Jordan, Prabhakar Arjun, O'Donnell Mike, Kuriyan John, Lamers Meindert H
Abstract excerpt
BACKGROUND: In addition to the core catalytic machinery, bacterial replicative DNA polymerases contain a Polymerase and Histidinol Phosphatase (PHP) domain whose function is not entirely understood. The PHP domains of some bacterial replicases are active metal-dependent nucleases that may play a role in proofreading. In E. coli DNA polymerase III, however, the PHP domain has lost several metal-coordinating...
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