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Article

The influence of XPD, APE1, XRCC1, and NBS1 polymorphic variants on DNA repair in cells exposed to X-rays.

Mutation research - 4 Jul 2013

Gdowicz-Klosok Agnieszka, Widel Maria, Rzeszowska-Wolny Joanna

Abstract excerpt

Polymorphism of genes coding for proteins which participate in DNA repair may predispose to or protect against development of cancer. Here we studied how common polymorphisms of the genes XPD (Asp312Asn and Lys751Gln), APE1 (Asp148Glu), XRCC1 (Arg399Gln), and NBS1 (Gln185Glu) influence DNA repair and other responses after X-irradiation of lymphocytes from colon carcinoma patients. Genotypes with polymorphic...

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Identifiers

PMID: 23669291
DOI: 10.1016/j.mrgentox.2013.05.002

Genes

XRCC1

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