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Article

The Zebrafish as a Model to Study Polycystic Liver Disease

13 May 2013

Abstract excerpt

In the polycystic liver diseases (PLD), genetic defects initiate the formation of cysts in the liver and kidney. In rodent models of PLD (i.e., the PCK rat and Pkd2(WS25/-) mouse), we have studied hepatorenal cystic disease and therapeutic approaches. In this study, we employed zebrafish injected with morpholinos against genes involved in the PLD, including sec63, prkcsh, and pkd1a. We calculated the liver cystic...

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PMID: 23668934
DOI: 10.1089/zeb.2012.0825

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