Article

Polycystic disease of the liver

2004-10-01

Abstract excerpt

Autosomal dominant polycystic disease is genetically heterogeneous with mutations in two distinct genes predisposing to the combination of renal and liver cysts (AD-PKD1 and AD-PKD2) and mutations in a third gene yielding isolated liver cysts (the polycystic liver disease gene). Transcription and translation of the PKD1 gene produces polycystin-1, an integral membrane protein that may serve as an extracellular rec...

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Literature Corpus work: 2ca85bf6-9b04-5534-84de-6ec60f3dc5cc
DOI: 10.1002/hep.1840400404

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