Age-related telomere uncapping is associated with cellular senescence and inflammation independent of telomere shortening in human arteries

Abstract excerpt

Arterial telomere dysfunction may contribute to chronic arterial inflammation by inducing cellular senescence and subsequent senescence-associated inflammation. Although telomere shortening has been associated with arterial aging in humans, age-related telomere uncapping has not been described in non-cultured human tissues and may have substantial prognostic value. In skeletal muscle feed arteries from 104...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Telomeres, Telomerase, and Senescence