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Article

Role of arterial telomere dysfunction in hypertension

31 Mar 2014

Abstract excerpt

OBJECTIVE: Telomere shortening in arteries could lead to telomere uncapping and cellular senescence, which in turn could promote the development of hypertension. METHODS AND RESULTS: To assess the novel role of arterial telomere dysfunction in hypertension, we compared mean telomere length (qPCR), telomere uncapping (serine 139 phosphorylated histone γ-H2A.X (γ-H2) localized to telomeres: ChIP), and tumor...

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PMID: 24686009
DOI: 10.1097/hjh.0000000000000157

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