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Article

NFATc2 recruits cJun homodimers to an NFAT site to synergistically activate interleukin-2 transcription.

Molecular immunology - 1 Nov 2013

Walters Ryan D, Drullinger Linda F, Kugel Jennifer F, Goodrich James A

Abstract excerpt

Transcription of interleukin-2 (IL-2), a pivotal cytokine in the mammalian immune response, is induced by NFAT and AP-1 transcriptional activators in stimulated T cells. NFATc2 and cJun drive high levels of synergistic human IL-2 transcription, which requires a unique interaction between the C-terminal activation domain of NFATc2 and cJun homodimers. Here we studied the mechanism by which this interaction...

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Identifiers

PMID: 23665382
DOI: 10.1016/j.molimm.2013.03.022
PMCID: PMC3686915

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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