Article
Distinct clinical outcomes of two CIMP-positive colorectal cancer subtypes based on a revised CIMP classification system.
British journal of cancer - 11 Apr 2017
Bae Jeong Mo, Kim Jung Ho, Kwak Yoonjin, Lee Dae-Won, Cha Yongjun, Wen Xianyu, Lee Tae Hun, Cho Nam-Yun, Jeong Seung-Yong, Park Kyu Joo, Han Sae Won, Lee Hye Seung, Kim Tae-You, Kang Gyeong Hoon
Abstract excerpt
BACKGROUND: Colorectal cancer (CRC) is a heterogeneous disease in terms of molecular carcinogenic pathways. Based on recent findings regarding the multiple serrated neoplasia pathway, we revised an eight-marker panel for a new CIMP classification system. METHODS: 1370 patients who received surgical resection for CRCs were classified into three CIMP subtypes (CIMP-N: 0-4 methylated markers, CIMP-P1: 5-6 methylated...
Topics
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
- Colorectal Neoplasms
- Combined Modality Therapy
- CpG Islands
- DNA Methylation
- Female
- Follow-Up Studies