Article
Clinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS): Implications for Clinical Trials.
JAMA neurology - 1 Jan 2016
Biglan Kevin Michael, Shoulson Ira, Kieburtz Karl, Oakes David, Kayson Elise, Shinaman M Aileen, Zhao Hongwei, Romer Megan, Young Anne, Hersch Steven, Penney Jack, Marder Karen, Paulsen Jane, Quaid Kimberly, Siemers Eric, Tanner Caroline, Mallonee William, Suter Greg, Dubinsky Richard, Gray Carolyn, Nance Martha, Bundlie Scott, Radtke Dawn, Kostyk Sandra, Baic Corrine, Caress James, Walker Francis, Hunt Victoria, O'Neill Christine, Chouinard Sylvain, Factor Stewart, Greenamyre Timothy, Wood-Siverio Cathy, Corey-Bloom Jody, Song David, Peavy Guerry, Moskowitz Carol, Wesson Melissa, Samii Ali, Bird Thomas, Lipe Hillary, Blindauer Karen, Marshall Frederick, Zimmerman Carol, Goldstein Jody, Rosas Diana, Novak Peter, Caviness John, Adler Charles, Duffy Amy, Wheelock Vicki, Tempkin Teresa, Richman David, Seeberger Lauren, Albin Roger, Chou Kelvin L, Racette Brad, Perlmutter Joel S, Perlman Susan, Bordelon Yvette, Martin Wayne, Wieler Marguerite, Leavitt Blair, Raymond Lynn, Decolongon Joji, Clarke Lorne, Jankovic Joseph, Hunter Christine, Hauser Robert A, Sanchez-Ramos Juan, Furtado Sarah, Suchowersky Oksana, Klimek Mary Lou, Guttman Mark, Sethna Rustom, Feigin Andrew, Cox Marie, Shannon Barbara, Percy Alan, Dure Leon, Harrison Madaline, Johnson William, Higgins Donald, Molho Eric, Nickerson Constance, Evans Sharon, Hobson Douglas, Singer Carlos, Galvez-Jimenez Nestor, Shannon Kathleen, Comella Cynthia, Ross Christopher, Saint-Hilaire Marie H, Testa Claudia, Rosenblatt Adam, Hogarth Penelope, Weiner William, Como Peter, Kumar Rajeev, Cotto Candace, Stout Julie, Brocht Alicia, Watts Arthur, Eberly Shirley, Weaver Christine, Foroud Tatiana, Gusella James, MacDonald Marcy, Myers Richard, Fahn Stanley, Shults Clifford
Abstract excerpt
IMPORTANCE: Identifying measures that are associated with the cytosine-adenine-guanine (CAG) expansion in individuals before diagnosis of Huntington disease (HD) has implications for designing clinical trials. OBJECTIVE: To identify the earliest features associated with the motor diagnosis of HD in the Prospective Huntington at Risk Observational Study (PHAROS). DESIGN, SETTING, AND PARTICIPANTS: A prospective,...
