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Article

Esophageal melanomas harbor frequent NRAS mutations unlike melanomas of other mucosal sites.

Virchows Archiv : an international journal of pathology - 1 May 2009

Sekine Shigeki, Nakanishi Yukihiro, Ogawa Reiko, Kouda Satoko, Kanai Yae

Abstract excerpt

Mucosal melanomas have genetic alterations distinct from those in cutaneous melanomas. For example, NRAS- and BRAF-activating mutations occur frequently in cutaneous melanomas, but not in mucosal melanomas. We examined 16 esophageal melanomas for genetic alterations in NRAS, BRAF, and KIT to determine whether they exhibit genetic features common to melanomas arising from other mucosal sites. A sequencing analysis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19319568
DOI: 10.1007/s00428-009-0762-6

Genes

KIT
NRAS
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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