Article
Dynamin GTPase regulation is altered by PH domain mutations found in centronuclear myopathy patients.
The EMBO journal - 15 Sept 2010
Kenniston Jon A, Lemmon Mark A
Abstract excerpt
The large GTPase dynamin has an important membrane scission function in receptor-mediated endocytosis and other cellular processes. Self-assembly on phosphoinositide-containing membranes stimulates dynamin GTPase activity, which is crucial for its function. Although the pleckstrin-homology (PH) domain is known to mediate phosphoinositide binding by dynamin, it remains unclear how this promotes activation. Here,...
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