Article
Identification of recurrent FGFR3 fusion genes in lung cancer through kinome-centred RNA sequencing.
The Journal of pathology - 1 Jul 2013
Majewski Ian J, Mittempergher Lorenza, Davidson Nadia M, Bosma Astrid, Willems Stefan M, Horlings Hugo M, de Rink Iris, Greger Liliana, Hooijer Gerrit K J, Peters Dennis, Nederlof Petra M, Hofland Ingrid, de Jong Jeroen, Wesseling Jelle, Kluin Roelof J C, Brugman Wim, Kerkhoven Ron, Nieboer Frank, Roepman Paul, Broeks Annegien, Muley Thomas R, Jassem Jacek, Niklinski Jacek, van Zandwijk Nico, Brazma Alvis, Oshlack Alicia, van den Heuvel Michel, Bernards René
Abstract excerpt
Oncogenic fusion genes that involve kinases have proven to be effective targets for therapy in a wide range of cancers. Unfortunately, the diagnostic approaches required to identify these events are struggling to keep pace with the diverse array of genetic alterations that occur in cancer. Diagnostic screening in solid tumours is particularly challenging, as many fusion genes occur with a low frequency. To...
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