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Article

T cell subsets differently regulate osteogenic differentiation of human mesenchymal stromal cells in vitro.

Journal of tissue engineering and regenerative medicine - 1 Apr 2016

Grassi Francesco, Cattini Luca, Gambari Laura, Manferdini Cristina, Piacentini Anna, Gabusi Elena, Facchini Andrea, Lisignoli Gina

Abstract excerpt

T lymphocytes play a key role in the regulation of bone homeostasis and bone healing. The inflammatory response at the site of bone injury is essential to the initiation of the bone repair program; however, an uncontrolled exposure to inflammatory environment has a negative effect on tissue regeneration - indeed, activated T cells were shown to inhibit osteogenic differentiation on human mesenchymal stromal cells...

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Source

Identifiers

PMID: 23653421
DOI: 10.1002/term.1727

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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