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Article

ERG Overexpression and PTEN Status Predict Capsular Penetration in Prostate Carcinoma

7 May 2013

Abstract excerpt

BACKGROUND: This study examines the combined effect of two common genetic alterations, ERG and PTEN, in prostate carcinoma progression. METHODS: Prostate tissue from 90 patients having unilateral capsular penetrating lesions, and a contra-lateral organ confined second lesion, were examined by immunohistochemistry for the expression of the TMPRSS2:ERG transformation product ERG and the loss of expression of PTEN,...

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PMID: 23653096
DOI: 10.1002/pros.22675

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