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Article

Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate.

Nature genetics - 1 May 2009

Carver Brett S, Tran Jennifer, Gopalan Anuradha, Chen Zhenbang, Shaikh Safa, Carracedo Arkaitz, Alimonti Andrea, Nardella Caterina, Varmeh Shohreh, Scardino Peter T, Cordon-Cardo Carlos, Gerald William, Pandolfi Pier Paolo

Abstract excerpt

Chromosomal translocations involving the ERG locus are frequent events in human prostate cancer pathogenesis; however, the biological role of aberrant ERG expression is controversial. Here we show that aberrant expression of ERG is a progression event in prostate tumorigenesis. We find that prost...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19396168
DOI: 10.1038/ng.370
PMCID: PMC2835150

Genes

ERG
PTEN
ADAMTS1
CXCR4
TMPRSS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19396168-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate.PMID 19396168Read ↗

The Expression of Proto-Oncogene ETS-Related Gene (ERG) Plays a Central Role in the Oncogenic Mechanism Involved in the Development and Progression of Prostate CancerSemantic proximity Read ↗

A causal role for ERG in neoplastic transformation of prostate epitheliumSemantic proximity Read ↗

Clinical Applications of Novel ERG Immunohistochemistry in Prostate Cancer Diagnosis and ManagementSemantic proximity Read ↗

Deletion of Interstitial Genes between TMPRSS2 and ERG Promotes Prostate Cancer ProgressionSemantic proximity Read ↗

ERG oncoprotein expression in prostate cancer: clonal progression of ERG-positive tumor cells and potential for ERG-based stratificationSemantic proximity Read ↗

ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss.Semantic proximity Read ↗

A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and ColonSemantic proximity Read ↗

Loss of FOXO1 Cooperates with TMPRSS2–ERG Overexpression to Promote Prostate Tumorigenesis and Cell InvasionSemantic proximity Read ↗

TMPRSS2-ERG Gene Fusion Causing ERG Overexpression Precedes Chromosome Copy Number Changes in Prostate Carcinomas, Paired HGPIN LesionsSemantic proximity Read ↗

TMPRSS2-ERG Controls Luminal Epithelial Lineage and Antiandrogen Sensitivity in PTEN and TP53 -Mutated Prostate CancerSemantic proximity Read ↗

TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.Semantic proximity Read ↗

Molecular evidence that invasive adenocarcinoma can mimic prostatic intraepithelial neoplasia ( PIN ) and intraductal carcinoma through retrograde glandular colonizationSemantic proximity Read ↗

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