Article
Allele-specific expression of angiotensinogen in human subcutaneous adipose tissue.
Hypertension (Dallas, Tex. : 1979) - 1 Jul 2013
Park Sungmi, Lu Ko-Ting, Liu Xuebo, Chatterjee Tapan K, Rudich Steven M, Weintraub Neal L, Kwitek Anne E, Sigmund Curt D
Abstract excerpt
The angiotensinogen gene is genetically linked with hypertension, but the mechanistic basis for association of sequence variants in the promoter and coding region of the gene remains unclear. An E-box at position -20 has been hypothesized to control the level of angiotensinogen expression, but its mechanistic importance for angiotensinogen expression in human tissues is uncertain. We developed an allele-specific...
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