Article
Recognition of a bacterial adhesion by an integrin: macrophage CR3 (alpha M beta 2, CD11b/CD18) binds filamentous hemagglutinin of Bordetella pertussis.
Cell - 29 Jun 1990
Relman D, Tuomanen E, Falkow S, Golenbock D T, Saukkonen K, Wright S D
Abstract excerpt
During the course of whooping cough, Bordetella pertussis interacts with alveolar macrophages and other leukocytes on the respiratory epithelium. We report here mechanisms by which these bacteria adhere to human macrophages in vitro. Whole bacteria adhere by means of two proteins, filamentous hem...
Topics
- Amino Acid Sequence
- Antibody Specificity
- Antigens, CD
- Bacterial Adhesion
- Base Sequence
- Bordetella pertussis
- Genotype
- Hemagglutinins
- Humans
- Integrins
- Macrophages
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Oligopeptides
- Plasmids
- Receptors, Immunologic
- Receptors, Peptide