Article
Human platelets recognize a novel surface protein, PadA, on Streptococcus gordonii through a unique interaction involving fibrinogen receptor GPIIbIIIa.
Infection and immunity - 1 Jan 2010
Petersen Helen J, Keane Ciara, Jenkinson Howard F, Vickerman M Margaret, Jesionowski Amy, Waterhouse Janet C, Cox Dermot, Kerrigan Steven W
Abstract excerpt
The concept of an infectious agent playing a role in cardiovascular disease is slowly gaining attention. Among several pathogens identified, the oral bacterium Streptococcus gordonii has been implicated as a plausible agent. Platelet adhesion and subsequent aggregation are critical events in the pathogenesis and dissemination of the infective process. Here we describe the identification and characterization of a...
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