Natural‐host animal models indicate functional interchangeability between the filamentous haemagglutinins of <i>Bordetella pertussis</i> and <i>Bordetella bronchiseptica</i> and reveal a role for the mature C‐terminal domain, but not the RGD motif, during infection

Abstract excerpt

Bacteria of the Bordetella genus cause respiratory tract infections. Both broad host range (e.g. Bordetella bronchiseptica) and human-adapted (e.g. Bordetella pertussis) strains produce a surface-exposed and secreted protein called filamentous haemagglutinin (FHA) that functions in adherence and immunomodulation. Previous studies using B. pertussis and cultured mammalian cells identified several FHA domains with...

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