<i>Bordetella</i> filamentous hemagglutinin plays a critical role in immunomodulation, suggesting a mechanism for host specificity

Abstract excerpt

Bordetella pertussis, the causative agent of the acute childhood respiratory disease whooping cough, is a human-adapted variant of Bordetella bronchiseptica, which displays a broad host range and typically causes chronic, asymptomatic infections. These pathogens express a similar but not identical surface-exposed and secreted protein called filamentous hemagglutinin (FHA) that has been proposed to function as...

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