Article
Bordetella pertussis naturally occurring isolates with altered lipooligosaccharide structure fail to fully mature human dendritic cells.
Infection and immunity - 1 Jan 2015
Brummelman Jolanda, Veerman Rosanne E, Hamstra Hendrik Jan, Deuss Anna J M, Schuijt Tim J, Sloots Arjen, Kuipers Betsy, van Els Cécile A C M, van der Ley Peter, Mooi Frits R, Han Wanda G H, Pinelli Elena
Abstract excerpt
Bordetella pertussis is a Gram-negative bacterium and the causative agent of whooping cough. Despite high vaccination coverage, outbreaks are being increasingly reported worldwide. Possible explanations include adaptation of this pathogen, which may interfere with recognition by the innate immune system. Here, we describe innate immune recognition and responses to different B. pertussis clinical isolates. By...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.