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Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis.

Biochimica et biophysica acta - 1 Jul 2009

Banerjee Rebecca, Starkov Anatoly A, Beal M Flint, Thomas Bobby

Abstract excerpt

Parkinson's disease (PD) is a progressive neurodegenerative movement disorder with unknown etiology. It is marked by widespread neurodegeneration in the brain with profound loss of A9 midbrain dopaminergic neurons in substantia nigra pars compacta. Several theories of biochemical abnormalities have been linked to pathogenesis of PD of which mitochondrial dysfunction due to an impairment of mitochondrial complex I...

Topics

Animals
Humans
Mitochondria
Mutation
Parkinson Disease

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 19059336
DOI: 10.1016/j.bbadis.2008.11.007
PMCID: PMC2867353

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