Article
Haloperidol promotes mTORC1-dependent phosphorylation of ribosomal protein S6 via dopamine- and cAMP-regulated phosphoprotein of 32 kDa and inhibition of protein phosphatase-1.
Neuropharmacology - 1 Sept 2013
Bonito-Oliva Alessandra, Pallottino Simone, Bertran-Gonzalez Jesus, Girault Jean-Antoine, Valjent Emmanuel, Fisone Gilberto
Abstract excerpt
The ribosomal protein S6 (rpS6) is a component of the small 40S ribosomal subunit, involved in multiple physiological functions. Here, we examined the effects produced by haloperidol, a typical antipsychotic drug, on the phosphorylation of rpS6 at Ser240/244 in the striatum, a brain region involved in neurodegenerative and neuropsychiatric disorders. We found that administration of haloperidol increased...
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