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Article

Two novel functional single nucleotide polymorphisms of ADRB3 are associated with type 2 diabetes in the Chinese population.

The Journal of clinical endocrinology and metabolism - 1 Jul 2013

Huang Qiong, Yang Tian-Lun, Tang Bei-Sha, Chen Xiang, Huang Xi, Luo Xiang-Hang, Zhu Yuan-Shan, Chen Xiao-Ping, Hu Ping-Cheng, Chen Juan, Wei Wei, Zhou Hong-Hao, Yin Ji-Ye, Liu Zhao-Qian

Abstract excerpt

AIMS: The purpose of this study was to investigate the association of two novel β3-adrenergic receptor (ADRB3) gene polymorphisms (Ser165Pro and Ser257Pro) with type 2 diabetes (T2DM) in the Chinese population. METHODS: A total of 650 patients with T2DM and 1337 health volunteers were enrolled to conduct the association study. Two candidate polymorphisms were recreated by site-directed mutagenesis and tested for...

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Identifiers

PMID: 23640967
DOI: 10.1210/jc.2013-1137

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ADRB3

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