Article
Evidence for core 2 to core 1 O-glycan remodeling during the recycling of MUC1.
Glycobiology - 1 Aug 2013
Razawi Hanieh, Kinlough Carol L, Staubach Simon, Poland Paul A, Rbaibi Youssef, Weisz Ora A, Hughey Rebecca P, Hanisch Franz-Georg
Abstract excerpt
The apical transmembrane glycoprotein MUC1 is endocytosed to recycle through the trans-Golgi network (TGN) or Golgi complex to the plasma membrane. We followed the hypothesis that not only the known follow-up sialylation of MUC1 in the TGN is associated with this process, but also a remodeling of O-glycan core structures, which would explain the previously described differential core 2- vs core 1-based...
Topics
- Amino Acid Sequence
- Animals
- Cell Membrane
- Dogs
- Endosomes
- Glycosylation
- Golgi Apparatus
- HEK293 Cells
- Humans
- MCF-7 Cells
- Madin Darby Canine Kidney Cells