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Article

Monitoring conformational changes in peroxisome proliferator-activated receptor α by a genetically encoded photoamino acid, cross-linking, and mass spectrometry.

Journal of medicinal chemistry - 13 Jun 2013

Schwarz Rico, Tänzler Dirk, Ihling Christian H, Müller Mathias Q, Kölbel Knut, Sinz Andrea

Abstract excerpt

Chemical cross-linking combined with an enzymatic digestion and mass spectrometric analysis of the reaction products has evolved into an alternative strategy to structurally resolve protein complexes. We investigated conformational changes in peroxisome proliferator-activated receptor α (PPARα) u...

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PMID: 23639233
DOI: 10.1021/jm400446b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23639233-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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