Article
Retinoic acid regulates morphogenesis and patterning of posterior foregut derivatives.
Developmental biology - 15 Sept 2006
Wang Zengxin, Dollé Pascal, Cardoso Wellington V, Niederreither Karen
Abstract excerpt
Retinoic acid (RA) is an embryonic signaling molecule regulating a wide array of target genes, thereby being a master regulator of patterning and differentiation in a variety of organs. Here we show that mouse embryos deficient for the RA-synthesizing enzyme retinaldehyde dehydrogenase 2 (RALDH2), if rescued from early lethality by maternal RA supplementation between E7.5 and E8.5, lack active RA signaling in the...
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