Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting photoreceptors via intravitreal delivery using novel, capsid-mutated AAV vectors.

PloS one - 1 Jan 2013

Kay Christine N, Ryals Renee C, Aslanidi George V, Min Seok Hong, Ruan Qing, Sun Jingfen, Dyka Frank M, Kasuga Daniel, Ayala Andrea E, Van Vliet Kim, Agbandje-McKenna Mavis, Hauswirth William W, Boye Sanford L, Boye Shannon E

Abstract excerpt

Development of viral vectors capable of transducing photoreceptors by less invasive methods than subretinal injection would provide a major advancement in retinal gene therapy. We sought to develop novel AAV vectors optimized for photoreceptor transduction following intravitreal delivery and to develop methodology for quantifying this transduction in vivo. Surface exposed tyrosine (Y) and threonine (T) residues...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Capsid
Share to Dependovirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Transfer Techniques

Share to Intravitreal Injections

Share to Photoreceptor Cells, Vertebrate

Share to Serotyping

Share to Transduction, Genetic

Share to Viral Tropism

Source

Open in PubMed Open full text

Identifiers

PMID: 23637972
DOI: 10.1371/journal.pone.0062097
PMCID: PMC3637363

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting photoreceptors via intravitreal delivery using novel, capsid-mutated AAV vectors.PMID 23637972Read ↗

Tyrosine capsid-mutant AAV vectors for gene delivery to the canine retina from a subretinal or intravitreal approach.Semantic proximity Read ↗

High-efficiency transduction of the mouse retina by tyrosine-mutant AAV serotype vectors.Semantic proximity Read ↗

AAV-mediated CRISPR/Cas gene editing of retinal cells <i>in vivo</i>Semantic proximity Read ↗

The Human Rhodopsin Kinase Promoter in an AAV5 Vector Confers Rod- and Cone-Specific Expression in the Primate RetinaSemantic proximity Read ↗

Retinal transduction profiling of diverse AAV serotypes via intravitreal injectionSemantic proximity Read ↗

Tropism of engineered and evolved recombinant AAV serotypes in the rd1 mouse and ex vivo primate retinaSemantic proximity Read ↗

Enhanced gene delivery to the neonatal retina through systemic administration of tyrosine-mutated AAV9.Semantic proximity Read ↗

Characterization of intravitreally delivered capsid mutant AAV2-Cre vector to induce tissue-specific mutations in murine retinal ganglion cells.Semantic proximity Read ↗

Exosome-associated AAV2 vector mediates robust gene delivery into the murine retina upon intravitreal injectionSemantic proximity Read ↗

Single AAV-mediated mutation replacement genome editing in limited number of photoreceptors restores vision in mice.Semantic proximity Read ↗

Ocular Gene Transfer with Self-Complementary AAV VectorsSemantic proximity Read ↗

Adeno-Associated Virus-Mediated Rhodopsin Replacement Provides Therapeutic Benefit in Mice with a Targeted Disruption of the Rhodopsin GeneSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.