Article

AAV-mediated CRISPR/Cas gene editing of retinal cells <i>in vivo</i>

2016-02-09

Abstract excerpt

<h4>ABSTRACT</h4> <h4>PURPOSE</h4> CRISPR/Cas has recently been adapted to enable efficient editing of the mammalian genome, opening novel avenues for therapeutic intervention of inherited diseases. In seeking to disrupt Yellow Fluorescent Protein (YFP) in a Thy1-YFP transgenic mouse, we assessed the feasibility of utilising the adeno-associated virus 2 (AAV2) to deliver CRISPR/Cas for gene modification of retin...

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Literature Corpus work: 88cf364a-efe0-517a-a7d4-e8ef50a16116
DOI: 10.1101/039156

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