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Vaccination with Trypomastigote Surface Antigen 1-Encoding Plasmid DNA Confers Protection against LethalTrypanosoma cruziInfection

1 Nov 1998

Abstract excerpt

DNA vaccination was evaluated with the experimental murine model of Trypanosoma cruzi infection as a means to induce antiparasite protective immunity, and the trypomastigote surface antigen 1 (TSA-1), a target of anti-T. cruzi antibody and major histocompatibility complex (MHC) class I-restricted CD8(+) cytotoxic T-lymphocyte (CTL) responses, was used as the model antigen. Following the intramuscular immunization...

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PMID: 9784506
DOI: 10.1128/iai.66.11.5073-5081.1998

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