Immunologically relevant strain polymorphism in the Amastigote Surface Protein 2 of Trypanosoma cruzi.

doi:10.1016/j.micinf.2007.04.006

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Article

Immunologically relevant strain polymorphism in the Amastigote Surface Protein 2 of Trypanosoma cruzi.

Microbes and infection - 1 Jul 2007

Claser Carla, Espíndola Noeli Maria, Sasso Gisela, Vaz Adelaide José, Boscardin Silvia B, Rodrigues Mauricio M

Abstract excerpt

Several evidences suggest that the Amastigote Surface Protein-2 (ASP-2) of Trypanosoma cruzi is an important target for immunity during infection. Based on this, we considered it important to evaluate its strain polymorphism. Initially, we observed the presence of conserved cross-reactive epitopes in amastigotes of all parasite strains tested. In addition, the predicted amino acid sequences of the genes isolated...

Topics

Amino Acid Sequence
Animals
Antigens, Protozoan
Chagas Disease
Cross Reactions
Epitopes
Female
Genetic Variation
HeLa Cells
Humans
Isoenzymes
Life Cycle Stages
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL

Source

Open in PubMed

Identifiers

PMID: 17548222
DOI: 10.1016/j.micinf.2007.04.006

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Molecular Sequence Data

Neuraminidase

Polymorphism, Genetic