Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Immunization Elicits Antigen-Specific Protective Immune Responses and Decreases Disease Severity inTrypanosoma cruziInfection

12 Sept 2002

Abstract excerpt

Immunity to Trypanosoma cruzi requires elicitation of humoral and cell-mediated immune responses to extracellular trypomastigotes and intracellular amastigotes. In this study, the effectiveness of the T. cruzi trans-sialidase family (ts) genes ASP-1, ASP-2, and TSA-1 as genetic vaccines was assessed. Immunization of mice with plasmids encoding ASP-1, ASP-2, or TSA-1 elicited poor antigen-specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Parasitic Infections and Diagnostics
Share to Research on Leishmaniasis Studies
Share to Trypanosoma species research and implications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12228281
DOI: 10.1128/iai.70.10.5547-5555.2002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Immunization Elicits Antigen-Specific Protective Immune Responses and Decreases Disease Severity inTrypanosoma cruziInfectionPMID 12228281Read ↗

Protective Immunity Against Trypanosoma cruzi Infection in a Highly Susceptible Mouse Strain After Vaccination with Genes Encoding the Amastigote Surface Protein-2 and Trans-SialidaseSemantic proximity Read ↗

Comparative evaluation of therapeutic DNA vaccines againstTrypanosoma cruziin miceSemantic proximity Read ↗

Vaccination with Trypomastigote Surface Antigen 1-Encoding Plasmid DNA Confers Protection against LethalTrypanosoma cruziInfectionSemantic proximity Read ↗

Comparison of antibody and protective immune responses against <i>Trypanosoma cruzi</i> infection elicited by immunization with a parasite antigen delivered as naked DNA or recombinant proteinSemantic proximity Read ↗

Immunization with cDNA Expressed by Amastigotes ofTrypanosoma cruziElicits Protective Immune Response against Experimental InfectionSemantic proximity Read ↗

The high identity of the Trypanosoma cruzi Group‐I of trans‐sialidases points them as promising vaccine immunogensSemantic proximity Read ↗

Genomic Analyses, Gene Expression and Antigenic Profile of the Trans-Sialidase Superfamily of Trypanosoma cruzi Reveal an Undetected Level of ComplexitySemantic proximity Read ↗

Gene-deleted live-attenuated<i>Trypanosoma cruzi</i>parasites as vaccines to protect against Chagas diseaseSemantic proximity Read ↗

Disruption of Active Trans-Sialidase Genes Impairs Egress from Mammalian Host Cells and Generates Highly Attenuated Trypanosoma cruzi ParasitesSemantic proximity Read ↗

CD8+ T-Cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopes.Semantic proximity Read ↗

The genetic immunization with paraflagellar rod protein-2 fused to the HSP70 confers protection against late Trypanosoma cruzi infectionSemantic proximity Read ↗

Vaccine against Trypanosoma cruzi infection using the Parasite Antigen TcTASV Displayed at Baculovirus CapsidSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.