Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.

doi:10.1038/mp.2013.138

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Article

Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.

Molecular psychiatry - 1 Sept 2014

Ruderfer Douglas M, Fanous Ayman H, Ripke Stephan, McQuillin Andrew, Amdur Richard L, Gejman Pablo V, O'Donovan Michael C, Andreassen Ole A, Djurovic Srdjan, Hultman Christina M, Kelsoe John R, Jamain Stephane, Landén Mikael, Leboyer Marion, Nimgaonkar Vishwajit, Nurnberger John, Smoller Jordan W, Craddock Nick, Corvin Aiden, Sullivan Patrick F, Holmans Peter, Sklar Pamela, Kendler Kenneth S

Abstract excerpt

Bipolar disorder and schizophrenia are two often severe disorders with high heritabilities. Recent studies have demonstrated a large overlap of genetic risk loci between these disorders but diagnostic and molecular distinctions still remain. Here, we perform a combined genome-wide association study (GWAS) of 19 779 bipolar disorder (BP) and schizophrenia (SCZ) cases versus 19 423 controls, in addition to a direct...

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PMID: 24280982
DOI: 10.1038/mp.2013.138
PMCID: PMC4033708

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