Article
Critical role of increased PTEN nuclear translocation in excitotoxic and ischemic neuronal injuries.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 May 2013
Zhang Shu, Taghibiglou Changiz, Girling Kimberly, Dong Zhifang, Lin Shinn-Zong, Lee Wei, Shyu Woei-cherng, Wang Yu Tian
Abstract excerpt
Stroke is the leading cause of disability in developed countries. However, no treatment is available beyond 3 h post-ictus. Here, we report that nuclear translocation of PTEN (phosphatase and tensin homolog deleted on chromosome TEN) is a delayed step causatively leading to excitotoxic (in vitro)...
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